RapamycinFungusV1, Main, Exploration, bibRecord, 000587

Hepatitis C Virus Modulates Solute carrier family 3 member 2 for Viral Propagation.

Identifieur interne : 000587 ( Main/Exploration ); précédent : 000586; suivant : 000588

Hepatitis C Virus Modulates Solute carrier family 3 member 2 for Viral Propagation.

Auteurs : Ngan N T. Nguyen [Corée du Sud] ; Yun-Sook Lim [Corée du Sud] ; Lap P. Nguyen [Corée du Sud] ; Si C. Tran [Corée du Sud] ; Trang T D. Luong [Corée du Sud] ; Tram T T. Nguyen [Corée du Sud] ; Hang T. Pham [Corée du Sud] ; Han N. Mai [Corée du Sud] ; Jae-Woong Choi [Corée du Sud] ; Sang-Seop Han [Corée du Sud] ; Soon B. Hwang [Corée du Sud]

Source :

Scientific reports [ 2045-2322 ] ; 2018.

RBID : pubmed:30341327

Descripteurs français

English descriptors

KwdEn :
- Fusion Regulatory Protein 1, Heavy Chain (genetics), Fusion Regulatory Protein 1, Heavy Chain (metabolism), Gene Expression Regulation (MeSH), HEK293 Cells (MeSH), Hepacivirus (physiology), Hepatitis C (virology), Humans (MeSH), Large Neutral Amino Acid-Transporter 1 (metabolism), Leucine (metabolism), Mechanistic Target of Rapamycin Complex 1 (metabolism), Multiprotein Complexes (metabolism), Oxidative Stress (MeSH), Protein Transport (MeSH), RNA, Small Interfering (genetics), Signal Transduction (MeSH), Viral Nonstructural Proteins (metabolism), Virus Internalization (MeSH), Virus Replication (MeSH).
MESH :
- chemical , genetics : Fusion Regulatory Protein 1, Heavy Chain, RNA, Small Interfering.
- chemical , metabolism : Fusion Regulatory Protein 1, Heavy Chain, Large Neutral Amino Acid-Transporter 1, Leucine, Mechanistic Target of Rapamycin Complex 1, Multiprotein Complexes, Viral Nonstructural Proteins.
- physiology : Hepacivirus.
- virology : Hepatitis C.
- Gene Expression Regulation, HEK293 Cells, Humans, Oxidative Stress, Protein Transport, Signal Transduction, Virus Internalization, Virus Replication.

Abstract

Hepatitis C virus (HCV) exploits an extensive network of host proteins to maintain chronic infection. Using RNA-Seq technology, we identified 30 host genes that were differentially expressed in cell culture grown HCV (HCVcc)-infected cells. Of these candidate genes, we selected solute carrier family 3 member 2 (SLC3A2) for further investigation. SLC3A2, also known as CD98hc, is a member of the solute carrier family and encodes a subunit of heterodimeric amino acid transporter. SLC3A2 and LAT1 constitute a heterodimeric transmembrane protein complex that catalyzes amino acid transport. In this study, we showed that HCV upregulated both mRNA and protein expression levels of SLC3A2 and this upregulation occurred through NS3/4A-mediated oxidative stress. HCV also elevated SLC3A2/LAT1 complex level and thus mammalian target of rapamycin complex 1 (mTORC1) signaling was activated. We further showed that L-leucine transport level was significantly increased in Jc1-infected cells as compared with mock-infected cells. Using RNA interference technology, we demonstrated that SLC3A2 was specifically required for the entry step but not for other stages of the HCV life cycle. These data suggest that SLC3A2 plays an important role in regulating HCV entry. Collectively, HCV exploits SLC3A2 for viral propagation and upregulation of SLC3A2 may contribute to HCV-mediated pathogenesis.

DOI: 10.1038/s41598-018-33861-6
PubMed: 30341327
PubMed Central: PMC6195511

Affiliations:

Corée du Sud

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000425
to stream Main, to step Curation: 000425

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hepatitis C Virus Modulates Solute carrier family 3 member 2 for Viral Propagation.</title>
<author><name sortKey="Nguyen, Ngan N T" sort="Nguyen, Ngan N T" uniqKey="Nguyen N" first="Ngan N T" last="Nguyen">Ngan N T. Nguyen</name>
<affiliation wicri:level="1"><nlm:affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang</wicri:regionArea>
<wicri:noRegion>Anyang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lim, Yun Sook" sort="Lim, Yun Sook" uniqKey="Lim Y" first="Yun-Sook" last="Lim">Yun-Sook Lim</name>
<affiliation wicri:level="1"><nlm:affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang</wicri:regionArea>
<wicri:noRegion>Anyang</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Chonbuk National University, Iksan, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Laboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Chonbuk National University, Iksan</wicri:regionArea>
<wicri:noRegion>Iksan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nguyen, Lap P" sort="Nguyen, Lap P" uniqKey="Nguyen L" first="Lap P" last="Nguyen">Lap P. Nguyen</name>
<affiliation wicri:level="1"><nlm:affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang</wicri:regionArea>
<wicri:noRegion>Anyang</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Chonbuk National University, Iksan, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Laboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Chonbuk National University, Iksan</wicri:regionArea>
<wicri:noRegion>Iksan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tran, Si C" sort="Tran, Si C" uniqKey="Tran S" first="Si C" last="Tran">Si C. Tran</name>
<affiliation wicri:level="1"><nlm:affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang</wicri:regionArea>
<wicri:noRegion>Anyang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Luong, Trang T D" sort="Luong, Trang T D" uniqKey="Luong T" first="Trang T D" last="Luong">Trang T D. Luong</name>
<affiliation wicri:level="1"><nlm:affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang</wicri:regionArea>
<wicri:noRegion>Anyang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nguyen, Tram T T" sort="Nguyen, Tram T T" uniqKey="Nguyen T" first="Tram T T" last="Nguyen">Tram T T. Nguyen</name>
<affiliation wicri:level="1"><nlm:affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang</wicri:regionArea>
<wicri:noRegion>Anyang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pham, Hang T" sort="Pham, Hang T" uniqKey="Pham H" first="Hang T" last="Pham">Hang T. Pham</name>
<affiliation wicri:level="1"><nlm:affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang</wicri:regionArea>
<wicri:noRegion>Anyang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mai, Han N" sort="Mai, Han N" uniqKey="Mai H" first="Han N" last="Mai">Han N. Mai</name>
<affiliation wicri:level="1"><nlm:affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang</wicri:regionArea>
<wicri:noRegion>Anyang</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Chonbuk National University, Iksan, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Laboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Chonbuk National University, Iksan</wicri:regionArea>
<wicri:noRegion>Iksan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Choi, Jae Woong" sort="Choi, Jae Woong" uniqKey="Choi J" first="Jae-Woong" last="Choi">Jae-Woong Choi</name>
<affiliation wicri:level="1"><nlm:affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang</wicri:regionArea>
<wicri:noRegion>Anyang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Han, Sang Seop" sort="Han, Sang Seop" uniqKey="Han S" first="Sang-Seop" last="Han">Sang-Seop Han</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Chonbuk National University, Iksan, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Laboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Chonbuk National University, Iksan</wicri:regionArea>
<wicri:noRegion>Iksan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hwang, Soon B" sort="Hwang, Soon B" uniqKey="Hwang S" first="Soon B" last="Hwang">Soon B. Hwang</name>
<affiliation wicri:level="1"><nlm:affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea. sbhwang@jbnu.ac.kr.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang</wicri:regionArea>
<wicri:noRegion>Anyang</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Chonbuk National University, Iksan, South Korea. sbhwang@jbnu.ac.kr.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Laboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Chonbuk National University, Iksan</wicri:regionArea>
<wicri:noRegion>Iksan</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2018">2018</date>
<idno type="RBID">pubmed:30341327</idno>
<idno type="pmid">30341327</idno>
<idno type="doi">10.1038/s41598-018-33861-6</idno>
<idno type="pmc">PMC6195511</idno>
<idno type="wicri:Area/Main/Corpus">000425</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000425</idno>
<idno type="wicri:Area/Main/Curation">000425</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000425</idno>
<idno type="wicri:Area/Main/Exploration">000425</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Hepatitis C Virus Modulates Solute carrier family 3 member 2 for Viral Propagation.</title>
<author><name sortKey="Nguyen, Ngan N T" sort="Nguyen, Ngan N T" uniqKey="Nguyen N" first="Ngan N T" last="Nguyen">Ngan N T. Nguyen</name>
<affiliation wicri:level="1"><nlm:affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang</wicri:regionArea>
<wicri:noRegion>Anyang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lim, Yun Sook" sort="Lim, Yun Sook" uniqKey="Lim Y" first="Yun-Sook" last="Lim">Yun-Sook Lim</name>
<affiliation wicri:level="1"><nlm:affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang</wicri:regionArea>
<wicri:noRegion>Anyang</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Chonbuk National University, Iksan, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Laboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Chonbuk National University, Iksan</wicri:regionArea>
<wicri:noRegion>Iksan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nguyen, Lap P" sort="Nguyen, Lap P" uniqKey="Nguyen L" first="Lap P" last="Nguyen">Lap P. Nguyen</name>
<affiliation wicri:level="1"><nlm:affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang</wicri:regionArea>
<wicri:noRegion>Anyang</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Chonbuk National University, Iksan, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Laboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Chonbuk National University, Iksan</wicri:regionArea>
<wicri:noRegion>Iksan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tran, Si C" sort="Tran, Si C" uniqKey="Tran S" first="Si C" last="Tran">Si C. Tran</name>
<affiliation wicri:level="1"><nlm:affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang</wicri:regionArea>
<wicri:noRegion>Anyang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Luong, Trang T D" sort="Luong, Trang T D" uniqKey="Luong T" first="Trang T D" last="Luong">Trang T D. Luong</name>
<affiliation wicri:level="1"><nlm:affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang</wicri:regionArea>
<wicri:noRegion>Anyang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nguyen, Tram T T" sort="Nguyen, Tram T T" uniqKey="Nguyen T" first="Tram T T" last="Nguyen">Tram T T. Nguyen</name>
<affiliation wicri:level="1"><nlm:affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang</wicri:regionArea>
<wicri:noRegion>Anyang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pham, Hang T" sort="Pham, Hang T" uniqKey="Pham H" first="Hang T" last="Pham">Hang T. Pham</name>
<affiliation wicri:level="1"><nlm:affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang</wicri:regionArea>
<wicri:noRegion>Anyang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mai, Han N" sort="Mai, Han N" uniqKey="Mai H" first="Han N" last="Mai">Han N. Mai</name>
<affiliation wicri:level="1"><nlm:affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang</wicri:regionArea>
<wicri:noRegion>Anyang</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Chonbuk National University, Iksan, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Laboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Chonbuk National University, Iksan</wicri:regionArea>
<wicri:noRegion>Iksan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Choi, Jae Woong" sort="Choi, Jae Woong" uniqKey="Choi J" first="Jae-Woong" last="Choi">Jae-Woong Choi</name>
<affiliation wicri:level="1"><nlm:affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang</wicri:regionArea>
<wicri:noRegion>Anyang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Han, Sang Seop" sort="Han, Sang Seop" uniqKey="Han S" first="Sang-Seop" last="Han">Sang-Seop Han</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Chonbuk National University, Iksan, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Laboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Chonbuk National University, Iksan</wicri:regionArea>
<wicri:noRegion>Iksan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hwang, Soon B" sort="Hwang, Soon B" uniqKey="Hwang S" first="Soon B" last="Hwang">Soon B. Hwang</name>
<affiliation wicri:level="1"><nlm:affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea. sbhwang@jbnu.ac.kr.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang</wicri:regionArea>
<wicri:noRegion>Anyang</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Chonbuk National University, Iksan, South Korea. sbhwang@jbnu.ac.kr.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Laboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Chonbuk National University, Iksan</wicri:regionArea>
<wicri:noRegion>Iksan</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Scientific reports</title>
<idno type="eISSN">2045-2322</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Fusion Regulatory Protein 1, Heavy Chain (genetics)</term>
<term>Fusion Regulatory Protein 1, Heavy Chain (metabolism)</term>
<term>Gene Expression Regulation (MeSH)</term>
<term>HEK293 Cells (MeSH)</term>
<term>Hepacivirus (physiology)</term>
<term>Hepatitis C (virology)</term>
<term>Humans (MeSH)</term>
<term>Large Neutral Amino Acid-Transporter 1 (metabolism)</term>
<term>Leucine (metabolism)</term>
<term>Mechanistic Target of Rapamycin Complex 1 (metabolism)</term>
<term>Multiprotein Complexes (metabolism)</term>
<term>Oxidative Stress (MeSH)</term>
<term>Protein Transport (MeSH)</term>
<term>RNA, Small Interfering (genetics)</term>
<term>Signal Transduction (MeSH)</term>
<term>Viral Nonstructural Proteins (metabolism)</term>
<term>Virus Internalization (MeSH)</term>
<term>Virus Replication (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Cellules HEK293 (MeSH)</term>
<term>Chaine lourde de l'antigène CD98 (génétique)</term>
<term>Chaine lourde de l'antigène CD98 (métabolisme)</term>
<term>Complexe-1 cible mécanistique de la rapamycine (métabolisme)</term>
<term>Complexes multiprotéiques (métabolisme)</term>
<term>Hepacivirus (physiologie)</term>
<term>Humains (MeSH)</term>
<term>Hépatite C (virologie)</term>
<term>Leucine (métabolisme)</term>
<term>Petit ARN interférent (génétique)</term>
<term>Protéines virales non structurales (métabolisme)</term>
<term>Pénétration virale (MeSH)</term>
<term>Régulation de l'expression des gènes (MeSH)</term>
<term>Réplication virale (MeSH)</term>
<term>Stress oxydatif (MeSH)</term>
<term>Transduction du signal (MeSH)</term>
<term>Transport des protéines (MeSH)</term>
<term>Transporteur-1 d'acides aminés neutres à longue chaîne (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Fusion Regulatory Protein 1, Heavy Chain</term>
<term>RNA, Small Interfering</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fusion Regulatory Protein 1, Heavy Chain</term>
<term>Large Neutral Amino Acid-Transporter 1</term>
<term>Leucine</term>
<term>Mechanistic Target of Rapamycin Complex 1</term>
<term>Multiprotein Complexes</term>
<term>Viral Nonstructural Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Chaine lourde de l'antigène CD98</term>
<term>Petit ARN interférent</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Chaine lourde de l'antigène CD98</term>
<term>Complexe-1 cible mécanistique de la rapamycine</term>
<term>Complexes multiprotéiques</term>
<term>Leucine</term>
<term>Protéines virales non structurales</term>
<term>Transporteur-1 d'acides aminés neutres à longue chaîne</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Hepacivirus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hepacivirus</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Hépatite C</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Hepatitis C</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Gene Expression Regulation</term>
<term>HEK293 Cells</term>
<term>Humans</term>
<term>Oxidative Stress</term>
<term>Protein Transport</term>
<term>Signal Transduction</term>
<term>Virus Internalization</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Cellules HEK293</term>
<term>Humains</term>
<term>Pénétration virale</term>
<term>Régulation de l'expression des gènes</term>
<term>Réplication virale</term>
<term>Stress oxydatif</term>
<term>Transduction du signal</term>
<term>Transport des protéines</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Hepatitis C virus (HCV) exploits an extensive network of host proteins to maintain chronic infection. Using RNA-Seq technology, we identified 30 host genes that were differentially expressed in cell culture grown HCV (HCVcc)-infected cells. Of these candidate genes, we selected solute carrier family 3 member 2 (SLC3A2) for further investigation. SLC3A2, also known as CD98hc, is a member of the solute carrier family and encodes a subunit of heterodimeric amino acid transporter. SLC3A2 and LAT1 constitute a heterodimeric transmembrane protein complex that catalyzes amino acid transport. In this study, we showed that HCV upregulated both mRNA and protein expression levels of SLC3A2 and this upregulation occurred through NS3/4A-mediated oxidative stress. HCV also elevated SLC3A2/LAT1 complex level and thus mammalian target of rapamycin complex 1 (mTORC1) signaling was activated. We further showed that L-leucine transport level was significantly increased in Jc1-infected cells as compared with mock-infected cells. Using RNA interference technology, we demonstrated that SLC3A2 was specifically required for the entry step but not for other stages of the HCV life cycle. These data suggest that SLC3A2 plays an important role in regulating HCV entry. Collectively, HCV exploits SLC3A2 for viral propagation and upregulation of SLC3A2 may contribute to HCV-mediated pathogenesis.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30341327</PMID>
<DateCompleted><Year>2019</Year>
<Month>12</Month>
<Day>12</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>12</Month>
<Day>17</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2045-2322</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>8</Volume>
<Issue>1</Issue>
<PubDate><Year>2018</Year>
<Month>10</Month>
<Day>19</Day>
</PubDate>
</JournalIssue>
<Title>Scientific reports</Title>
<ISOAbbreviation>Sci Rep</ISOAbbreviation>
</Journal>
<ArticleTitle>Hepatitis C Virus Modulates Solute carrier family 3 member 2 for Viral Propagation.</ArticleTitle>
<Pagination><MedlinePgn>15486</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/s41598-018-33861-6</ELocationID>
<Abstract><AbstractText>Hepatitis C virus (HCV) exploits an extensive network of host proteins to maintain chronic infection. Using RNA-Seq technology, we identified 30 host genes that were differentially expressed in cell culture grown HCV (HCVcc)-infected cells. Of these candidate genes, we selected solute carrier family 3 member 2 (SLC3A2) for further investigation. SLC3A2, also known as CD98hc, is a member of the solute carrier family and encodes a subunit of heterodimeric amino acid transporter. SLC3A2 and LAT1 constitute a heterodimeric transmembrane protein complex that catalyzes amino acid transport. In this study, we showed that HCV upregulated both mRNA and protein expression levels of SLC3A2 and this upregulation occurred through NS3/4A-mediated oxidative stress. HCV also elevated SLC3A2/LAT1 complex level and thus mammalian target of rapamycin complex 1 (mTORC1) signaling was activated. We further showed that L-leucine transport level was significantly increased in Jc1-infected cells as compared with mock-infected cells. Using RNA interference technology, we demonstrated that SLC3A2 was specifically required for the entry step but not for other stages of the HCV life cycle. These data suggest that SLC3A2 plays an important role in regulating HCV entry. Collectively, HCV exploits SLC3A2 for viral propagation and upregulation of SLC3A2 may contribute to HCV-mediated pathogenesis.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nguyen</LastName>
<ForeName>Ngan N T</ForeName>
<Initials>NNT</Initials>
<AffiliationInfo><Affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lim</LastName>
<ForeName>Yun-Sook</ForeName>
<Initials>YS</Initials>
<AffiliationInfo><Affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Chonbuk National University, Iksan, South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nguyen</LastName>
<ForeName>Lap P</ForeName>
<Initials>LP</Initials>
<AffiliationInfo><Affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Chonbuk National University, Iksan, South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tran</LastName>
<ForeName>Si C</ForeName>
<Initials>SC</Initials>
<AffiliationInfo><Affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Luong</LastName>
<ForeName>Trang T D</ForeName>
<Initials>TTD</Initials>
<AffiliationInfo><Affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nguyen</LastName>
<ForeName>Tram T T</ForeName>
<Initials>TTT</Initials>
<AffiliationInfo><Affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pham</LastName>
<ForeName>Hang T</ForeName>
<Initials>HT</Initials>
<AffiliationInfo><Affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mai</LastName>
<ForeName>Han N</ForeName>
<Initials>HN</Initials>
<AffiliationInfo><Affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Chonbuk National University, Iksan, South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Choi</LastName>
<ForeName>Jae-Woong</ForeName>
<Initials>JW</Initials>
<AffiliationInfo><Affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Han</LastName>
<ForeName>Sang-Seop</ForeName>
<Initials>SS</Initials>
<AffiliationInfo><Affiliation>Laboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Chonbuk National University, Iksan, South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hwang</LastName>
<ForeName>Soon B</ForeName>
<Initials>SB</Initials>
<AffiliationInfo><Affiliation>National Research Laboratory of Hepatitis C Virus, Hallym University, Anyang, South Korea. sbhwang@jbnu.ac.kr.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Laboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Chonbuk National University, Iksan, South Korea. sbhwang@jbnu.ac.kr.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>2018R1A2B2005390</GrantID>
<Agency>National Research Foundation of Korea (NRF)</Agency>
<Country>International</Country>
</Grant>
<Grant><GrantID>2017R1C1B2004989</GrantID>
<Agency>Ministry of Science, ICT and Future Planning (MSIP)</Agency>
<Country>International</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>10</Month>
<Day>19</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Sci Rep</MedlineTA>
<NlmUniqueID>101563288</NlmUniqueID>
<ISSNLinking>2045-2322</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D027282">Fusion Regulatory Protein 1, Heavy Chain</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D027283">Large Neutral Amino Acid-Transporter 1</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D046912">Multiprotein Complexes</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C084422">NS3 protein, hepatitis C virus</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D034741">RNA, Small Interfering</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C545989">SLC3A2 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D017361">Viral Nonstructural Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="D000076222">Mechanistic Target of Rapamycin Complex 1</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>GMW67QNF9C</RegistryNumber>
<NameOfSubstance UI="D007930">Leucine</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D027282" MajorTopicYN="N">Fusion Regulatory Protein 1, Heavy Chain</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005786" MajorTopicYN="N">Gene Expression Regulation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D057809" MajorTopicYN="N">HEK293 Cells</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016174" MajorTopicYN="N">Hepacivirus</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006526" MajorTopicYN="N">Hepatitis C</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D027283" MajorTopicYN="N">Large Neutral Amino Acid-Transporter 1</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007930" MajorTopicYN="N">Leucine</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000076222" MajorTopicYN="N">Mechanistic Target of Rapamycin Complex 1</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D046912" MajorTopicYN="N">Multiprotein Complexes</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D021381" MajorTopicYN="N">Protein Transport</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D034741" MajorTopicYN="N">RNA, Small Interfering</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017361" MajorTopicYN="N">Viral Nonstructural Proteins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053586" MajorTopicYN="N">Virus Internalization</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year>
<Month>07</Month>
<Day>20</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2018</Year>
<Month>10</Month>
<Day>04</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2018</Year>
<Month>10</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2018</Year>
<Month>10</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2019</Year>
<Month>12</Month>
<Day>18</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">30341327</ArticleId>
<ArticleId IdType="doi">10.1038/s41598-018-33861-6</ArticleId>
<ArticleId IdType="pii">10.1038/s41598-018-33861-6</ArticleId>
<ArticleId IdType="pmc">PMC6195511</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>World J Gastroenterol. 2014 Apr 7;20(13):3457-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24707128</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gastroenterol Hepatol. 2010 Mar;25(3):627-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20074151</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Viruses. 2013 Jan 28;5(2):439-69</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23358390</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Biochem Cell Biol. 2015 Oct;67:25-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26256001</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oxid Med Cell Longev. 2016;2016:9012580</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26955431</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Hepatology. 2013 Feb;57(2):492-504</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23081796</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2012 Aug;86(16):8705-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22674982</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Cell Biol. 2017 Jun;96(4):325-336</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28427795</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2015 Oct;89(19):10073-86</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26202252</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):355-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15625115</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2006 May 9;103(19):7408-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16651538</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Physiol Rev. 1998 Oct;78(4):969-1054</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9790568</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Physiol Cell Physiol. 2001 Oct;281(4):C1077-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11546643</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Hepatol. 2005 Oct;43(4):606-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16112247</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Microbiol. 2013 Oct;11(10):688-700</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24018384</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2012 Feb 10;287(7):5042-58</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22184107</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2012 Aug 1;429(2):112-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22560863</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2012 May;86(9):4868-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22345471</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2013 Jul;19(7):837-49</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23836234</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Cancer Res. 2015 Mar 15;5(4):1281-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26101697</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cancer. 2013 Dec 21;12:169</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24359579</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Adv Drug Deliv Rev. 2007 Oct 10;59(12):1200-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17825945</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cell Sci. 2012 Mar 15;125(Pt 6):1373-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22499670</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gastroenterol Hepatol. 2006 Oct;21 Suppl 3:S34-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16958669</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Rep. 2016 Feb 10;6:20819</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26860204</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2015 Mar 21;385(9973):1124-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25687730</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2011 Sep 2;286(35):30361-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21737455</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2009 Feb 6;136(3):521-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19203585</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Physiol Endocrinol Metab. 2012 Jun 1;302(11):E1329-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22354780</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Anim Nutr. 2018 Sep;4(3):329-337</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30175263</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2006 Nov;80(22):11331-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16943299</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2016 Apr 29;291(18):9700-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26945935</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Microbiol. 2017 Jun 19;8:1129</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28674529</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2007 Apr 12;446(7137):801-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17325668</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FASEB J. 2007 Aug;21(10):2474-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17392480</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2010 Jul 2;285(27):20870-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20439463</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Cancer Drug Targets. 2017;17(6):498-504</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27677955</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Clin Invest. 2009 Apr;39(4):304-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19292886</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Hepatol. 2014 Nov;61(1 Suppl):S45-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25086286</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Biochem Cell Biol. 2016 Dec;81(Pt A):148-150</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27840151</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Corée du Sud</li>
</country>
</list>
<tree><country name="Corée du Sud"><noRegion><name sortKey="Nguyen, Ngan N T" sort="Nguyen, Ngan N T" uniqKey="Nguyen N" first="Ngan N T" last="Nguyen">Ngan N T. Nguyen</name>
</noRegion>
<name sortKey="Choi, Jae Woong" sort="Choi, Jae Woong" uniqKey="Choi J" first="Jae-Woong" last="Choi">Jae-Woong Choi</name>
<name sortKey="Han, Sang Seop" sort="Han, Sang Seop" uniqKey="Han S" first="Sang-Seop" last="Han">Sang-Seop Han</name>
<name sortKey="Hwang, Soon B" sort="Hwang, Soon B" uniqKey="Hwang S" first="Soon B" last="Hwang">Soon B. Hwang</name>
<name sortKey="Hwang, Soon B" sort="Hwang, Soon B" uniqKey="Hwang S" first="Soon B" last="Hwang">Soon B. Hwang</name>
<name sortKey="Lim, Yun Sook" sort="Lim, Yun Sook" uniqKey="Lim Y" first="Yun-Sook" last="Lim">Yun-Sook Lim</name>
<name sortKey="Lim, Yun Sook" sort="Lim, Yun Sook" uniqKey="Lim Y" first="Yun-Sook" last="Lim">Yun-Sook Lim</name>
<name sortKey="Luong, Trang T D" sort="Luong, Trang T D" uniqKey="Luong T" first="Trang T D" last="Luong">Trang T D. Luong</name>
<name sortKey="Mai, Han N" sort="Mai, Han N" uniqKey="Mai H" first="Han N" last="Mai">Han N. Mai</name>
<name sortKey="Mai, Han N" sort="Mai, Han N" uniqKey="Mai H" first="Han N" last="Mai">Han N. Mai</name>
<name sortKey="Nguyen, Lap P" sort="Nguyen, Lap P" uniqKey="Nguyen L" first="Lap P" last="Nguyen">Lap P. Nguyen</name>
<name sortKey="Nguyen, Lap P" sort="Nguyen, Lap P" uniqKey="Nguyen L" first="Lap P" last="Nguyen">Lap P. Nguyen</name>
<name sortKey="Nguyen, Tram T T" sort="Nguyen, Tram T T" uniqKey="Nguyen T" first="Tram T T" last="Nguyen">Tram T T. Nguyen</name>
<name sortKey="Pham, Hang T" sort="Pham, Hang T" uniqKey="Pham H" first="Hang T" last="Pham">Hang T. Pham</name>
<name sortKey="Tran, Si C" sort="Tran, Si C" uniqKey="Tran S" first="Si C" last="Tran">Si C. Tran</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000587 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000587 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    RapamycinFungusV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:30341327
   |texte=   Hepatitis C Virus Modulates Solute carrier family 3 member 2 for Viral Propagation.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:30341327" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a RapamycinFungusV1

This area was generated with Dilib version V0.6.38.
Data generation: Thu Nov 19 21:55:41 2020. Site generation: Thu Nov 19 22:00:39 2020

	Serveur d'exploration sur la rapamycine et les champignons
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la rapamycine et les champignons

Hepatitis C Virus Modulates Solute carrier family 3 member 2 for Viral Propagation.

Hepatitis C Virus Modulates Solute carrier family 3 member 2 for Viral Propagation.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki